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Article

GWAS Identifies DPP6 as Risk Gene of Cognitive Decline in Parkinson's Disease.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Aug 2024

Li Chunyu, Hou Yanbing, Ou Ruwei, Wei Qianqian, Zhang Lingyu, Liu Kuncheng, Lin Junyu, Chen Xueping, Song Wei, Zhao Bi, Wu Ying, Shang Huifang

Abstract excerpt

BACKGROUND: Cognitive decline is among the most common non-motor symptoms in Parkinson's disease (PD), while its physiological mechanisms remain poorly understood. Genetic factors constituted a fundamental determinant in the heterogeneity of cognitive decline among PD patients. However, the underlying genetic background was still less studied. METHODS: To explore the genetic determinants contributing to cognitive...

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China
Cognitive Dysfunction
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
Longitudinal Studies
Nerve Tissue Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parkinson Disease

Potassium Channels

Proportional Hazards Models

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PMID: 38875006
DOI: 10.1093/gerona/glae155
PMCID: PMC11272050

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