Article
Genetic variation in the glucagon-like peptide-1 receptor protein encoding region is associated with higher heart rate variability, but not with neurodegeneration of the brain, retina, and peripheral nerves: The Maastricht study.
Cardiovascular diabetology - 14 Oct 2025
van der Heide Frank C T, Steens Indra L M, Singh-Manoux Archana, Sabia Séverine, Zhou Tan Lai, Köhler Sebastian, Schram Miranda T, van der Kallen Carla J H, Berendschot Tos T J M, Webers Carroll A B, van Greevenbroek Marleen M J, Wesselius Anke, Arts Ilja C W, Jansen Jacobus F A, Backes Walter H, van Sloten Thomas T, Blokland Gabriëlla A M, Stehouwer Coen D A
Abstract excerpt
BACKGROUND: Degeneration of organ-specific nervous systems precede major clinical conditions such as heart failure, dementia, diabetic retinopathy, and diabetic neuropathy. Glucagon-like peptide-1 receptor (GLP1R) agonists may have neuroprotective effects, independent of their glucose-lowering effects, and as such may be tools for early prevention of neurodegeneration. We investigated whether genetic variation in...
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- Humans
- Male
- Female
- Middle Aged