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Article

Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD.

Diabetes care - 1 Feb 2018

Shah Hetal S, Morieri Mario Luca, Marcovina Santica M, Sigal Ronald J, Gerstein Hertzel C, Wagner Michael J, Motsinger-Reif Alison A, Buse John B, Kraft Peter, Mychaleckyj Josyf C, Doria Alessandro

Abstract excerpt

OBJECTIVE: A genome-wide association study in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial identified two markers (rs57922 and rs9299870) that were significantly associated with cardiovascular mortality during intensive glycemic control and could potentially be used, when combined into a genetic risk score (GRS), to identify patients with diabetes likely to derive benefit from intensive...

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Identifiers

PMID: 29183908
DOI: 10.2337/dc17-1638
PMCID: PMC5780047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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