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Article

Association of GLP1R locus with mental ill-health endophenotypes and cardiometabolic traits: A trans-ancestry study in UK Biobank.

Diabetes, obesity & metabolism - 1 Apr 2025

Hayman Madeleine M E, Jones Waneisha, Aman Alisha, Ward Joey, Anderson Jana, Lyall Donald M, Pell Jill P, Sattar Naveed, Welsh Paul, Strawbridge Rona J

Abstract excerpt

AIMS: Glucagon-like peptide 1 receptor agonists (GLP1RA), used to treat type 2 diabetes and obesity, have been associated with off-target behavioural effects. We systematically assessed genetic variation in the GLP1R locus for impact on mental ill-health (MIH) and cardiometabolic phenotypes across diverse populations within UK Biobank. MATERIALS AND METHODS: All genetic variants with minor allele frequency >1% in...

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Identifiers

PMID: 39838854
DOI: 10.1111/dom.16178
PMCID: PMC11885074

Genes

GLP1R

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