Article
Genetic Evidence for Repurposing of GLP1R (Glucagon-Like Peptide-1 Receptor) Agonists to Prevent Heart Failure.
Journal of the American Heart Association - 6 Jul 2021
Daghlas Iyas, Karhunen Ville, Ray Devleena, Zuber Verena, Burgess Stephen, Tsao Philip S, Lynch Julie A, Lee Kyung Min, Voight Benjamin F, Chang Kyong-Mi, Baker Emma H, Damrauer Scott M, Howson Joanna M M, Vujkovic Marijana, Gill Dipender
Abstract excerpt
Background This study was designed to investigate the genetic evidence for repurposing of GLP1R (glucagon-like peptide-1 receptor) agonists to prevent heart failure (HF) and whether the potential benefit exceeds the benefit conferred by more general glycemic control. Methods and Results We applied 2-sample Mendelian randomization of genetically proxied GLP1R agonism on HF as the main outcome and left ventricular...
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