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Article

Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response.

Diabetologia - 1 Aug 2009

Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling T M, Barroso I, Loos R J F, Wareham N J, Walker M

Abstract excerpt

AIMS/HYPOTHESIS: We investigated whether variation in MTNR1B, which was recently identified as a common genetic determinant of fasting glucose levels in healthy, diabetes-free individuals, is associated with measures of beta cell function and whole-body insulin sensitivity. METHODS: We studied 1,276 healthy individuals of European ancestry at 19 centres of the Relationship between Insulin Sensitivity and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melatonin, MT2

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Source

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Identifiers

PMID: 19455304
DOI: 10.1007/s00125-009-1392-x
PMCID: PMC2709880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response.PMID 19455304Read ↗

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.Semantic proximity Read ↗

Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function.Semantic proximity Read ↗

Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort.Semantic proximity Read ↗

Genetic variants in MTNR1B affecting insulin secretion.Semantic proximity Read ↗

MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans.Semantic proximity Read ↗

Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS.Semantic proximity Read ↗

Association between the melatonin receptor 1B gene polymorphism on the risk of type 2 diabetes, impaired glucose regulation: a meta-analysis.Semantic proximity Read ↗

The MTNR1B Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjects.Semantic proximity Read ↗

Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians.Semantic proximity Read ↗

A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals.Semantic proximity Read ↗

Variants in MTNR1B influence fasting glucose levels.Semantic proximity Read ↗

MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai.Semantic proximity Read ↗

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