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GLP1R gene expression is associated with metabolic and mental health effects in a phenome-wide drug repurposing and safety analysis

2025-10-15

Abstract excerpt

Glucagon-like peptide-1 receptor agonists (GLP1RAs) are transformative therapies for diabetes and obesity, yet their long-term clinical effects are incompletely understood. To address this, we conducted a phenome-wide association study (PheWAS) to assess potential therapeutic and adverse effects of GLP1RAs using genetic drug proxies near the GLP1R locus. Fifteen variants associated with GLP1R expression in the Gen...

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Literature Corpus work
ece55386-64fc-53dd-9dfc-411d60380de5
DOI
10.1101/2025.10.13.25337903
Open publication

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GLP1R gene expression is associated with metabolic and mental health effects in a phenome-wide drug repurposing and safety analysisDOI 10.1101/2025.10.13.25337903
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