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Article

Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation.

Cell metabolism - 3 Dec 2013

Xu Xiaoyuan, Grijalva Ambar, Skowronski Alicja, van Eijk Marco, Serlie Mireille J, Ferrante Anthony W

Abstract excerpt

Obesity activates a complex systemic immune response that includes the recruitment of macrophages and other immune cells to key metabolic tissues. Current models postulate that obesity and excess lipids classically activate macrophages, polarizing them toward an M1 (inflammatory) state. Little is known about noninflammatory functions of adipose tissue macrophages (ATMs). Here, we show that the expansion of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24315368
DOI: 10.1016/j.cmet.2013.11.001
PMCID: PMC3939841

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ATM

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