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Article

Rapid restoration of cell phenotype and matrix forming capacity following transient nuclear softening.

Acta biomaterialia - 1 Dec 2025

Locke Ryan C, Miller Liane M, Lemmon Elisabeth A, Assi Sereen S, Jones Dakota L, Bonnevie Edward D, Burdick Jason A, Heo Su Jin, Mauck Robert L

Abstract excerpt

The dense extracellular matrix of connective tissues impedes cell migration and subsequent matrix formation at sites of injury. We recently employed transient histone deacetylase inhibition with trichostatin A (TSA) treatment to increase nuclear deformability (decrease nuclear stiffness) to overcome the stiff nuclear impediments to cell migration through dense tissues and electrospun matrices. Despite these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41072595
DOI: 10.1016/j.actbio.2025.10.007
PMCID: PMC13052731

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