Epstein-Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA-DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset.

doi:10.1002/ana.78043

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Epstein-Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA-DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset.

Annals of neurology - 1 Feb 2026

Simpson-Yap Steve, Morwitch Ellen, Tanner Samuel A, Thomson Sarah M, Eisner Alex, Lea Rod A, Kilpatrick Trevor J, Lechner-Scott Jeannette, Scott Rodney J, Xavier Alexandre, Maltby Vicki E, Lucas Robyn M, Taylor Bruce V, Lidbury Brett A, Broadley Simon A, van der Mei Ingrid, Merid Mehari Woldemariam, Novakovic Boris, Saffery Richard, Hedström Anna Karin, Stridh Pernilla, Olsson Tomas, Jagodic Maja, Alfredsson Lars, Ponsonby Anne-Louise

Abstract excerpt

OBJECTIVES: Multiple sclerosis (MS) onset risk factors include Epstein-Barr virus (EBV) indices (including host response), lower serum 25-vitamin D (25(OH)D) levels, low sun exposure, and HLA-DRB1*1501. The underlying molecular mechanisms are unclear. Here, we examined mediation through differential DNA methylation (DNAm) to better understand possible epigenetic programming. METHODS: Two case-control studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41070760
DOI: 10.1002/ana.78043
PMCID: PMC12894492

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