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Article

Admixture-mapping analysis reveals genetic determinants of the human plasma proteome.

HGG advances - 15 Jan 2026

Cruz Daniel E, Deng Shuliang, Tahir Usman A, Chen Zsu-Zsu, Benson Mark D, Tuftin Bjoernar, Chen Jiawen, Farrell Laurie, Shen Dongxiao, Meyer Mariah, Lange Ethan, Gao Yan, Hall Michael E, Tracy Russell P, Rich Stephen S, Taylor Kent, Manichaikul Ani, Rotter Jerome I, Sofer Tamar, Wilson James G, Gerszten Robert E, Raffield Laura M

Abstract excerpt

Protein profiling and genetic findings can be integrated to define the genetic architecture of the circulating proteome in chronic diseases. Most self-identified African American (AA) individuals have both African and European genetic ancestry. Admixture mapping can detect genomic association regions in which causal variants exist with substantial differences in allele frequency or effect sizes between genetic...

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PMID: 41069105
DOI: 10.1016/j.xhgg.2025.100529
PMCID: PMC12657719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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