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Article

RANKL and CSF-1 are elevated in periovulatory follicular fluid of BRCA1 mutation carriers and increase proinflammatory signaling in fallopian tube epithelial cells.

Neoplasia (New York, N.Y.) - 1 Dec 2025

Kollara Alexandra, Madaan Vidushi, Zhang Jianhong, Greenblatt Ellen M, Brown Theodore J

Abstract excerpt

Pathogenic germline mutations in BRCA1 predispose individuals to high-grade serous tubo-ovarian cancer (HGSTOC), which originates in the fallopian tube epithelium (FTE). Identified non-genetic risk factors are consistent with a potential role for repetitive exposure of FTE cells to follicular fluid during ovulation in the development of this disease. We previously showed that BRCA1 deficiency in non-malignant FTE...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41067178
DOI: 10.1016/j.neo.2025.101237
PMCID: PMC12546688

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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RANKL and CSF-1 are elevated in periovulatory follicular fluid of BRCA1 mutation carriers and increase proinflammatory signaling in fallopian tube epithelial cells.PMID 41067178Read ↗

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