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Article

BRCA1 Mutation Status and Follicular Fluid Exposure Alters NFκB Signaling and ISGylation in Human Fallopian Tube Epithelial Cells.

Neoplasia (New York, N.Y.) - 1 Jul 2018

Hollingsworth Julia, Lau Angela, Tone Alicia, Kollara Alexandra, Allen Lisa, Colgan Terence J, Dube Valerie, Rosen Barry, Murphy K Joan, Greenblatt Ellen M, Feigenberg Tomer, Virtanen Carl, Brown Theodore J

Abstract excerpt

Germline BRCA1 or BRCA2 mutations (mtBRCA1 and mtBRCA2) increase risk for high-grade serous ovarian cancer (HGSOC), the most commonly diagnosed epithelial ovarian cancer histotype. Other identified risk factors for this cancer, which originates primarily in the distal fallopian tube epithelium (FTE), implicate ovulation, during which the FTE cells become transiently exposed to follicular fluid (FF). To test...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29852322
DOI: 10.1016/j.neo.2018.05.005
PMCID: PMC6030391

Genes

BRCA1
BRCA2
EGFR
ISG15

Provenance

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BRCA1 Mutation Status and Follicular Fluid Exposure Alters NFκB Signaling and ISGylation in Human Fallopian Tube Epithelial Cells.PMID 29852322Read ↗

RANKL and CSF-1 are elevated in periovulatory follicular fluid of BRCA1 mutation carriers and increase proinflammatory signaling in fallopian tube epithelial cells.Semantic proximity Read ↗

Integrative Transcriptome Analyses of the Human Fallopian Tube: Fimbria and Ampulla—Site of Origin of Serous Carcinoma of the OvarySemantic proximity Read ↗

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Prolonged Postovulatory Proinflammatory Signaling in the Fallopian Tube Epithelium May Be Mediated through a BRCA1/DAB2 AxisSemantic proximity Read ↗

BRCA and Early Events in the Development of Serous Ovarian CancerSemantic proximity Read ↗

Comparison of expression profiles in ovarian epithelium in vivo and ovarian cancer identifies novel candidate genes involved in disease pathogenesis.Semantic proximity Read ↗

Proliferation in the normal FTE is a hallmark of the follicular phase, not BRCA mutation status.Semantic proximity Read ↗

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