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BRCA and Early Events in the Development of Serous Ovarian Cancer

1 Jan 2014

Abstract excerpt

Women who have an inherited mutation in the BRCA1 or BRCA2 genes have a substantial increased lifetime risk of developing epithelial ovarian cancer (EOC), and epidemiological factors related to parity, ovulation, and hormone regulation have a dramatic effect on the risk in both BRCA mutation carriers and non-carriers. The most common and most aggressive histotype of EOC, high-grade serous carcinoma (HGSC), is...

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PMID: 24478985
DOI: 10.3389/fonc.2014.00005

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