Article
Dissection of transcriptome dysregulation and immune characterization in women with germline BRCA1 mutation at single-cell resolution.
BMC medicine - 9 Sept 2022
Yu Xuexin, Lin Wanrun, Spirtos Alexandra, Wang Yan, Chen Hao, Ye Jianfeng, Parker Jessica, Liu Ci Ci, Wang Yiying, Quinn Gabriella, Zhou Feng, Chambers Setsuko K, Lewis Cheryl, Lea Jayanthi, Li Bo, Zheng Wenxin
Abstract excerpt
BACKGROUND: High-grade serous carcinoma (HGSC) is the most frequent and lethal type of ovarian cancer. It has been proposed that tubal secretory cells are the origin of ovarian HGSC in women with familial BRCA1/2 mutations. However, the molecular changes underlying malignant transformation remain unknown. METHOD: We performed single-cell RNA and T cell receptor sequencing of tubal fimbriated ends from 3 BRCA1...
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