Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of abrogated pathways in fallopian tube epithelium from BRCA1 mutation carriers.

The Journal of pathology - 1 Sept 2011

George Sophia Hl, Greenaway James, Milea Anca, Clary Victoria, Shaw Sanjeev, Sharma Monika, Virtanen Carl, Shaw Patricia A

Abstract excerpt

The discovery of occult invasive and intra-epithelial tubal carcinomas in BRCA1 mutation carriers undergoing prophylactic surgery has implicated the fallopian tube epithelium as the source of serous cancer. However, little is known of the early molecular events of serous oncogenesis, or why cancers in BRCA1 mutation carriers are found preferentially in tissues which are responsive to reproductive hormones. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cystadenocarcinoma, Serous
Share to Epithelium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fallopian Tube Neoplasms

Share to Fallopian Tubes

Share to Genes, BRCA1

Share to Microdissection

Share to Oligonucleotide Array Sequence Analysis

Share to Precancerous Conditions

Source

Identifiers

PMID: 21744340
DOI: 10.1002/path.2927

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of abrogated pathways in fallopian tube epithelium from BRCA1 mutation carriers.PMID 21744340Read ↗

Identification of a preneoplastic gene expression profile in tubal epithelium of BRCA1 mutation carriers.Semantic proximity Read ↗

BRCA and Early Events in the Development of Serous Ovarian CancerSemantic proximity Read ↗

Candidate serous cancer precursors in fallopian tube epithelium of BRCA1/2 mutation carriers.Semantic proximity Read ↗

Gene expression profiles of luteal phase fallopian tube epithelium from BRCA mutation carriers resemble high-grade serous carcinoma.Semantic proximity Read ↗

RANKL and CSF-1 are elevated in periovulatory follicular fluid of BRCA1 mutation carriers and increase proinflammatory signaling in fallopian tube epithelial cells.Semantic proximity Read ↗

Dissection of transcriptome dysregulation and immune characterization in women with germline BRCA1 mutation at single-cell resolution.Semantic proximity Read ↗

Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancer.Semantic proximity Read ↗

A candidate precursor to serous carcinoma that originates in the distal fallopian tube.Semantic proximity Read ↗

Challenges in the early diagnosis and staging of Fallopian-tube carcinomas associated with BRCA mutations.Semantic proximity Read ↗

Integrative Transcriptome Analyses of the Human Fallopian Tube: Fimbria and Ampulla—Site of Origin of Serous Carcinoma of the OvarySemantic proximity Read ↗

Serous carcinogenesis in the fallopian tube: a descriptive classification.Semantic proximity Read ↗

The molecular pathogenesis of hereditary ovarian carcinoma: alterations in the tubal epithelium of women with BRCA1 and BRCA2 mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.