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Article

Identification of a preneoplastic gene expression profile in tubal epithelium of BRCA1 mutation carriers.

Neoplasia (New York, N.Y.) - 1 Dec 2010

Press Joshua Z, Wurz Kaitlyn, Norquist Barbara M, Lee Ming K, Pennil Christopher, Garcia Rochelle, Welcsh Piri, Goff Barbara A, Swisher Elizabeth M

Abstract excerpt

Microinvasive carcinomas and high-grade intraepithelial neoplasms are commonly discovered within the fallopian tube of BRCA1 mutation carriers at the time of risk-reducing salpingo-oophorectomy, suggesting that many BRCA1-mutated ovarian carcinomas originate in tubal epithelium. We hypothesized t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 21170264
DOI: 10.1593/neo.101044
PMCID: PMC3003134

Genes

BRCA1
BRCA2
EFEMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21170264-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Identification of a preneoplastic gene expression profile in tubal epithelium of BRCA1 mutation carriers.PMID 21170264Read ↗

Identification of abrogated pathways in fallopian tube epithelium from BRCA1 mutation carriers.Semantic proximity Read ↗

The molecular pathogenesis of hereditary ovarian carcinoma: alterations in the tubal epithelium of women with BRCA1 and BRCA2 mutations.Semantic proximity Read ↗

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The tubal epigenome - An emerging target for ovarian cancer.Semantic proximity Read ↗

Candidate serous cancer precursors in fallopian tube epithelium of BRCA1/2 mutation carriers.Semantic proximity Read ↗

Challenges in the early diagnosis and staging of Fallopian-tube carcinomas associated with BRCA mutations.Semantic proximity Read ↗

Transitional cell metaplasia of fallopian tube fimbriae: a potential mimic of early tubal carcinoma in risk reduction salpingo-oophorectomies from women With BRCA mutations.Semantic proximity Read ↗

Spatial Transcriptomic Analysis of Ovarian Cancer Precursors Reveals Reactivation of IGFBP2 during PathogenesisSemantic proximity Read ↗

RANKL and CSF-1 are elevated in periovulatory follicular fluid of BRCA1 mutation carriers and increase proinflammatory signaling in fallopian tube epithelial cells.Semantic proximity Read ↗

Gene expression profiles of luteal phase fallopian tube epithelium from BRCA mutation carriers resemble high-grade serous carcinoma.Semantic proximity Read ↗

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