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Article

Prolonged Postovulatory Proinflammatory Signaling in the Fallopian Tube Epithelium May Be Mediated through a BRCA1/DAB2 Axis

3 Jul 2012

Abstract excerpt

PURPOSE: To assess inflammation-related gene expression in nonmalignant fallopian tube epithelium (FTE) from BRCA1/2 mutation carriers and control patients obtained during the luteal and follicular phase, and to determine the impact of BRCA1 and disabled homolog 2 (DAB2) on NF-κB-mediated proinflammatory signaling. EXPERIMENTAL DESIGN: A list of inflammation-related and NF-κB-responsive genes was compiled through...

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PMID: 22753593
DOI: 10.1158/1078-0432.ccr-12-0199

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