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Article

Sex and smoking bias in the selection of somatic mutations in human bladder.

Nature - 1 Nov 2025

Calvet Ferriol, Blanco Martinez-Illescas Raquel, Muiños Ferran, Tretiakova Maria, Latorre-Esteves Elena S, Fredrickson Jeanne, Andrianova Maria, Pellegrini Stefano, Huber Axel Rosendahl, Ramis-Zaldivar Joan Enric, An Shuyi Charlotte, Thieme Elana, Kohrn Brendan F, Grau Miguel L, Gonzalez-Perez Abel, Lopez-Bigas Nuria, Risques Rosa Ana

Abstract excerpt

Men are at higher risk of several cancer types than women1. For bladder cancer the risk is four times higher for reasons that are not clear2. Smoking is also a principal risk factor for several tumour types, including bladder cancer3. As tumourigenesis is driven by somatic mutations, we wondered whether the landscape of clones in the normal bladder differs by sex and smoking history. Using ultradeep duplex DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41062697
DOI: 10.1038/s41586-025-09521-x
PMCID: PMC12611770

Genes

ARID1A
CDKN1A
RBM10
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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