Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes.

doi:10.1038/s41467-022-30694-w

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Article

Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes.

Nature communications - 15 Jun 2022

Bustoros Mark, Anand Shankara, Sklavenitis-Pistofidis Romanos, Redd Robert, Boyle Eileen M, Zhitomirsky Benny, Dunford Andrew J, Tai Yu-Tzu, Chavda Selina J, Boehner Cody, Neuse Carl Jannes, Rahmat Mahshid, Dutta Ankit, Casneuf Tineke, Verona Raluca, Kastritis Efstathis, Trippa Lorenzo, Stewart Chip, Walker Brian A, Davies Faith E, Dimopoulos Meletios-Athanasios, Bergsagel P Leif, Yong Kwee, Morgan Gareth J, Aguet François, Getz Gad, Ghobrial Irene M

Abstract excerpt

Smoldering multiple myeloma (SMM) is a precursor condition of multiple myeloma (MM) with significant heterogeneity in disease progression. Existing clinical models of progression risk do not fully capture this heterogeneity. Here we integrate 42 genetic alterations from 214 SMM patients using unsupervised binary matrix factorization (BMF) clustering and identify six distinct genetic subtypes. These subtypes are...

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PMID: 35705541
DOI: 10.1038/s41467-022-30694-w
PMCID: PMC9200804

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