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Genetic Subtypes of Smoldering Multiple Myeloma are associated with Distinct Pathogenic Phenotypes and Clinical Outcomes

2021-12-11

Abstract excerpt

Smoldering multiple myeloma (SMM) is a precursor condition of multiple myeloma (MM) with significant heterogeneity in disease progression. Existing clinical models of progression risk do not fully capture this heterogeneity. Here we integrated 42 genetic alterations from 214 SMM patients using unsupervised binary matrix factorization (BMF) clustering and identified six distinct genetic subtypes. These subtypes wer...

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Literature Corpus work
c0288f21-9024-5bef-9724-0cf692ba9faa
DOI
10.1101/2021.12.10.471975
Open publication

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Genetic Subtypes of Smoldering Multiple Myeloma are associated with Distinct Pathogenic Phenotypes and Clinical OutcomesDOI 10.1101/2021.12.10.471975
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