Article
Heritability of Atrial Fibrillation.
Circulation. Cardiovascular genetics - 1 Dec 2017
Weng Lu-Chen, Choi Seung Hoan, Klarin Derek, Smith J Gustav, Loh Po-Ru, Chaffin Mark, Roselli Carolina, Hulme Olivia L, Lunetta Kathryn L, Dupuis Josée, Benjamin Emelia J, Newton-Cheh Christopher, Kathiresan Sekar, Ellinor Patrick T, Lubitz Steven A
Abstract excerpt
BACKGROUND: Previous reports have implicated multiple genetic loci associated with AF, but the contributions of genome-wide variation to AF susceptibility have not been quantified. METHODS AND RESULTS: We assessed the contribution of genome-wide single-nucleotide polymorphism variation to AF risk (single-nucleotide polymorphism heritability, h2g ) using data from 120 286 unrelated individuals of European ancestry...
Topics
- Aged
- Atrial Fibrillation
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Linkage Disequilibrium
- Male
- Middle Aged