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Article

Rare and Common Genetic Variation Underlying Atrial Fibrillation Risk.

JAMA cardiology - 1 Aug 2024

Vad Oliver B, Monfort Laia M, Paludan-Müller Christian, Kahnert Konstantin, Diederichsen Søren Z, Andreasen Laura, Lotta Luca A, Nielsen Jonas B, Lundby Alicia, Svendsen Jesper H, Olesen Morten S

Abstract excerpt

Importance: Atrial fibrillation (AF) has a substantial genetic component. The importance of polygenic risk is well established, while the contribution of rare variants to disease risk warrants characterization in large cohorts. Objective: To identify rare predicted loss-of-function (pLOF) variants associated with AF and elucidate their role in risk of AF, cardiomyopathy (CM), and heart failure (HF) in combination...

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Identifiers

PMID: 38922602
DOI: 10.1001/jamacardio.2024.1528
PMCID: PMC11209175

Genes

CTNNA3
KDM5B
PKP2
RPL3L
TTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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