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Article

Age-Dependent Contributions of Rare and Common Genetic Variation in Atrial Fibrillation.

Circulation. Genomic and precision medicine - 1 Oct 2025

Chen Zhanlin, Aziz Peter F, Greenland Philip, Passman Rod, Gordon Adam S, Webster Gregory

Abstract excerpt

BACKGROUND: Genetic variation contributes to atrial fibrillation (AF), but its impact may vary with age. The All of Us Research Program contains whole-genome sequencing of data from 100 574 adult participants with linked electronic health records. METHODS: We assessed clinical, monogenic, and polygenic associations with AF in a cross-sectional analysis, stratified by age: <45 years (n=22 290), 45 to 60 years...

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Topics

Humans
Atrial Fibrillation
Middle Aged
Male
Female
Aged
Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Age Factors

Genetic Variation

Adult

Multifactorial Inheritance

Genetic Predisposition to Disease

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 40931808
DOI: 10.1161/CIRCGEN.124.004958
PMCID: PMC12646633

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