Article

Rare coding variant architecture and gene discovery from 130,000 sequenced cases of atrial fibrillation

2026-05-04

Abstract excerpt

<title>Abstract</title> <p> Rare coding genetic variants may exert large effects on risk of common disease, yet their contribution to disease architecture and their utility in gene prioritization remain limited by inadequate sample sizes. Here, we performed a massive-scale rare variant association study (RVAS), analyzing over 1.1 million sequenced participants among which 130,000 had atrial fibrillation (AF). Th...

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Literature Corpus work: 125fd152-e72c-5a67-8e8a-0060040f88bf
DOI: 10.21203/rs.3.rs-9191644/v1

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