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Article

Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation.

Circulation - 6 Mar 2018

Weng Lu-Chen, Preis Sarah R, Hulme Olivia L, Larson Martin G, Choi Seung Hoan, Wang Biqi, Trinquart Ludovic, McManus David D, Staerk Laila, Lin Honghuang, Lunetta Kathryn L, Ellinor Patrick T, Benjamin Emelia J, Lubitz Steven A

Abstract excerpt

BACKGROUND: The long-term probability of developing atrial fibrillation (AF) considering genetic predisposition and clinical risk factor burden is unknown. METHODS: We estimated the lifetime risk of AF in individuals from the community-based Framingham Heart Study. Polygenic risk for AF was derived using a score of ≈1000 AF-associated single-nucleotide polymorphisms. Clinical risk factor burden was calculated for...

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Identifiers

PMID: 29129827
DOI: 10.1161/CIRCULATIONAHA.117.031431
PMCID: PMC5840011

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Source receipt: pubmed, retrieved 7 Sept 2026.

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