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African American exome sequencing identifies potential risk variants at Alzheimer disease loci

1 Apr 2017

Abstract excerpt

OBJECTIVE: In African Americans, we sought to systematically identify coding Alzheimer disease (AD) risk variants at the previously reported AD genome-wide association study (GWAS) loci genes. METHODS: We identified coding variants within genes at the 20 published AD GWAS loci by whole-exome sequencing of 238 African American participants, validated these in 300 additional participants, and tested their...

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PMID: 28480329
DOI: 10.1212/nxg.0000000000000141

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