Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of human GLI in mice results in failure to thrive, early death, and patchy Hirschsprung-like gastrointestinal dilatation.

Molecular medicine (Cambridge, Mass.) - 1 Dec 1997

Yang J T, Liu C Z, Villavicencio E H, Yoon J W, Walterhouse D, Iannaccone P M

Abstract excerpt

BACKGROUND: GLI is an oncodevelopmental gene in the vertebrate hedgehog/patched signaling pathway that is spatiotemporally regulated during development and is amplified in a subset of human cancers. GLI is the prototype for the Gli-Kruppel family of transcription factors, which includes the Droso...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Southern
Share to Gene Expression Regulation, Developmental
Share to Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Pedigree

Share to Phenotype

Share to Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 9440116
PMCID: PMC2230283

Genes

GLI3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9440116-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of human GLI in mice results in failure to thrive, early death, and patchy Hirschsprung-like gastrointestinal dilatation.PMID 9440116Read ↗

Identification of GLI Mutations in Patients With Hirschsprung Disease That Disrupt Enteric Nervous System Development in Mice.Semantic proximity Read ↗

Pallister-Hall syndrome phenotype in mice mutant for Gli3.Semantic proximity Read ↗

Gli proteins encode context-dependent positive and negative functions: implications for development and diseaseSemantic proximity Read ↗

The Sonic Hedgehog–Patched–Gli Pathway in Human Development and DiseaseSemantic proximity Read ↗

The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription Factors in Gene Regulation and DiseasesSemantic proximity Read ↗

GliFHV mice: a tool to investigate GLI processing and localization.Semantic proximity Read ↗

Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling.Semantic proximity Read ↗

Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans.Semantic proximity Read ↗

TALPID3/KIAA0586 regulates multiple aspects of neuromuscular patterning during gastrointestinal development in animal models and humanSemantic proximity Read ↗

New mouse models of congenital anorectal malformations.Semantic proximity Read ↗

Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features.Semantic proximity Read ↗

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.