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Article

Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivo.

Genes & development - 1 Jun 2026

Unger Lucas, Larsen Ulrik, Legøy Thomas Aga, Hossain Md Kaykobad, Gudmestad June Helen, Friestad Amanda, Sharmine Shayla, Njølstad Pål Rasmus, Ræder Helge, Herrera Pedro Luis, Ghila Luiza, Chera Simona

Abstract excerpt

Regulatory circuits driving regional cell fate specification and lineage restriction decisions are not fully understood. The molecular mechanisms by which Hedgehog signaling controls lineage segregation in the posterior foregut remain unclear. Here, we employed bulk and single-cell transcriptomics, microscopy, physiology, and genetic cell tracing in differentiating human induced pluripotent stem cells and mouse...

Topics

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Cell Lineage
Duodenum
Hedgehog Proteins
Hepatocyte Nuclear Factor 1-alpha
Induced Pluripotent Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nerve Tissue Proteins

Zinc Finger Protein Gli3

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Open in PubMed Open full text

Identifiers

PMID: 41887801
DOI: 10.1101/gad.353153.125
PMCID: PMC13224867

Genes

GLI3
HNF1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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