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Article

Differences in genetics and microenvironment of lung adenocarcinoma patients with or without TP53 mutation.

BMC pulmonary medicine - 11 Oct 2021

Zeng Dejun, Hu Zhengyang, Yi Yanjun, Valeria Besskaya, Shan Guangyao, Chen Zhencong, Zhan Cheng, Lin Miao, Lin Zongwu, Wang Qun

Abstract excerpt

BACKGROUND: Differences in genetics and microenvironment of LUAD patients with or without TP53 mutation were analyzed to illustrate the role of TP53 mutation within the carcinogenesis of LUAD, which will provide new concepts for the treatment of LUAD. METHODS: In this study, we used genetics and clinical info from the TCGA database, including somatic mutations data, RNA-seq, miRNA-seq, and clinical data. More...

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Identifiers

PMID: 34635074
DOI: 10.1186/s12890-021-01671-8
PMCID: PMC8507221

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