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Article

The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis.

Nature communications - 4 Jul 2016

Ben-David Uri, Ha Gavin, Khadka Prasidda, Jin Xin, Wong Bang, Franke Lude, Golub Todd R

Abstract excerpt

Aneuploidy and copy-number alterations (CNAs) are a hallmark of human cancer. Although genetically engineered mouse models (GEMMs) are commonly used to model human cancer, their chromosomal landscapes remain underexplored. Here we use gene expression profiles to infer CNAs in 3,108 samples from 45 mouse models, providing the first comprehensive catalogue of chromosomal aberrations in cancer GEMMs. Mining this...

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PMID: 27374210
DOI: 10.1038/ncomms12160
PMCID: PMC4932194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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