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Article

Genomic diversity and BCL9L mutational status in circulating tumor cells predict overall survival in metastatic colorectal cancer.

Cellular oncology (Dordrecht, Netherlands) - 1 Dec 2025

Alves Joao M, Estévez-Gómez Nuria, Piñeiro Roberto, Muinelo-Romay Laura, Mondelo-Macía Patricia, Salgado Mercedes, Iglesias-Gómez Agueda, Codesido-Prada Laura, Diez-Martín Astrid, Cubiella Joaquin, Posada David

Abstract excerpt

BACKGROUND: Metastatic colorectal cancer (mCRC) remains a major cause of cancer-related mortality, but few noninvasive biomarkers exist to track disease progression or inform treatment strategies. Circulating tumor cells (CTCs) offer a minimally invasive source of tumor material, yet the prognostic significance of their genomic diversity remains unclear. METHODS: We conducted whole-exome sequencing of CTC pools...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41051593
DOI: 10.1007/s13402-025-01109-x
PMCID: PMC12698839

Genes

BCL9L

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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