Article
Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing.
Cancer research - 15 May 2013
Heitzer Ellen, Auer Martina, Gasch Christin, Pichler Martin, Ulz Peter, Hoffmann Eva Maria, Lax Sigurd, Waldispuehl-Geigl Julie, Mauermann Oliver, Lackner Carolin, Höfler Gerald, Eisner Florian, Sill Heinz, Samonigg Hellmut, Pantel Klaus, Riethdorf Sabine, Bauernhofer Thomas, Geigl Jochen B, Speicher Michael R
Abstract excerpt
Circulating tumor cells (CTC) released into blood from primary cancers and metastases reflect the current status of tumor genotypes, which are prone to changes. Here, we conducted the first comprehensive genomic profiling of CTCs using array-comparative genomic hybridization (CGH) and next-generation sequencing. We used the U.S. Food and Drug Administration-cleared CellSearch system, which detected CTCs in 21 of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.