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Article

The role of cerebrospinal fluid metabolites in mediating the impact of lipids on Late-Onset Alzheimer's Disease: a two-step mendelian randomization analysis.

Journal of translational medicine - 28 Nov 2024

Jie Jie, Gong Yonglu, Hu Hongbo, Liu Su

Abstract excerpt

BACKGROUND: Although research has indicated correlations between lipids, cerebrospinal fluid (CSF) metabolites, and Late-Onset Alzheimer's Disease (LOAD), the specific causal relationships among these elements, as well as the roles and mechanisms of the cerebrospinal fluid metabolites, remain unclear. METHODS: Statistical datasets derived from Genome-Wide Association Studies (GWAS) were utilized to assess the...

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Age of Onset
Aged
Alzheimer Disease
Genome-Wide Association Study
Lipids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

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Identifiers

PMID: 39609832
DOI: 10.1186/s12967-024-05796-2
PMCID: PMC11603644

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PC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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