HMGCR genetic variability in Parkinson's disease in a Spanish cohort: associations with lipid metabolism and early onset.

doi:10.1007/s00415-025-13404-6

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Article

HMGCR genetic variability in Parkinson's disease in a Spanish cohort: associations with lipid metabolism and early onset.

Journal of neurology - 2 Oct 2025

Díaz-Belloso Rafael, Martín-Bornez Miguel, Macías-García Daniel, García-Díaz Sergio, Bonilla-Toribio Marta, Buiza-Rueda Dolores, Sánchez Rocío Pineda, Muñoz-Delgado Laura, Ojeda Elena, Jesús Silvia, Adarmes-Gómez Astrid, Carrillo Fátima, Mir Pablo, Gómez-Garre Pilar

Abstract excerpt

Lipid metabolism has emerged as a key factor in the pathophysiology of Parkinson's disease (PD). While 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol biosynthesis, has been implicated in neurodegenerative disorders, such as Alzheimer disease, its role in PD remains unexplored. Given the shared pathological features between these neurodegenerative disorders (such...

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Topics

Humans
Hydroxymethylglutaryl CoA Reductases
Male
Female
Parkinson Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Spain

Middle Aged

Age of Onset

Lipid Metabolism

Aged

Cohort Studies

Adult

Genetic Predisposition to Disease

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 41037108
DOI: 10.1007/s00415-025-13404-6
PMCID: PMC12491363

Genes

HMGCR

Provenance

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