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Genetic Associations of Lipid-Lowering Drugs and Parkinson’s Disease: A Mendelian Randomization Study

2024-01-16

Abstract excerpt

<h4>Background</h4> There is a need to establish the role of lipid-lowering agents as a therapeutic option for Parkinson’s Disease (PD), but its associations remain elusive. This study investigated genetic variants proxying lipid-lowering agents through HMGCR, NPC1L1, and PCSK9 inhibitors to determine casual associations with PD risk. <h4>Methods</h4> We utilized a two-sample Mendelian randomization (MR) framework...

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Literature Corpus work
6b73096c-f44e-598b-8a56-ebc42a6d3285
DOI
10.1101/2024.01.14.24301288
Open publication

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