Article

Mapping the causal chain from genetic risk variants to lipid dysmetabolism in Parkinson’s disease

2025-07-15

Abstract excerpt

Risk variants in multiple genes, including GBA1 , strongly implicate lipid metabolism in Parkinson’s disease (PD) onset and progression. We show that common PD risk variants at the serine palmitoyltransferase small subunit B ( SPTSSB ) locus, a key regulator of de novo sphingolipid biosynthesis, are associated with increased SPTSSB brain expression and elevated plasma ceramides. Additional analyses strongly suppor...

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Identifiers and source

Literature Corpus work: 69dad581-93b0-5048-8060-057030fa576c
DOI: 10.1101/2025.07.14.25331535

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