Mapping the causal chain from genetic risk variants to lipid dysmetabolism in Parkinson's disease.

doi:10.1093/brain/awag039

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Article

Mapping the causal chain from genetic risk variants to lipid dysmetabolism in Parkinson's disease.

Brain : a journal of neurology - 7 Sept 2026

De-Paula Ruth B, Kim Jonggeol, Rhinn Herve, Saade Hiba, Chavez Fatima, Segura Téah, Lozano Maria Valeria, Etoundi Michelle, Silos Karla, Kass Naomi, Korchina Viktoriya, Doddapaneni Harshavardhan, Venner Eric, Masdeu Joseph C, Pavlik Valory, Yu Melissa M, Lin Chi-Ying R, Jankovic Joseph, Buchman Aron S, Muzny Donna, Gibbs Richard A, Elsea Sarah H, Abeliovich Asa, Lansbury Peter, Vanegas-Arroyave Nora, Shaw Chad A, Shulman Joshua M

Abstract excerpt

The molecular pathways linking genetic variants to Parkinson's disease (PD) onset and progression remain incompletely defined; however, risk alleles in multiple genes, including GBA1, strongly implicate lipid metabolism. To systematically identify causal biomarker signatures, we analysed comprehensive metabolome profiles from blood plasma in 149 PD patients and 150 controls, along with complementary genetic,...

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Topics

Humans
Parkinson Disease
Lipid Metabolism
Serine C-Palmitoyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Male

Genetic Predisposition to Disease

Brain

Quantitative Trait Loci

Sphingolipids

Aged

Genetic Variation

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 41627849
DOI: 10.1093/brain/awag039
PMCID: PMC13548858

Genes

SPTSSB
GBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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