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Deviation From Genetically Predicted BMI and All-Cause Mortality: A Cohort Study in the UK Biobank.

Obesity (Silver Spring, Md.) - 1 Jan 2026

Zilhao Nuno R, Zhang Jie, Boomsma Dorret I, Sørensen Thorkild I A, Dahm Christina C

Abstract excerpt

OBJECTIVE: The relation between genetically predicted BMI (gBMI) and actual BMI may have health effects. This study examines the relationship between deviations from gBMI and all-cause mortality in 208,146 UK Biobank participants. METHODS: We derived gBMI from polygenic risk scores, with deviations calculated as the difference between observed and predicted BMI. Cox proportional hazards models are adjusted for...

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Identifiers

PMID: 41036672
DOI: 10.1002/oby.70042
PMCID: PMC12724034

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