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Article

Identification and analysis of individuals who deviate from their genetically-predicted phenotype.

PLoS genetics - 1 Sept 2023

Hawkes Gareth, Yengo Loic, Vedantam Sailaja, Marouli Eirini, Beaumont Robin N, Tyrrell Jessica, Weedon Michael N, Hirschhorn Joel, Frayling Timothy M, Wood Andrew R

Abstract excerpt

Findings from genome-wide association studies have facilitated the generation of genetic predictors for many common human phenotypes. Stratifying individuals misaligned to a genetic predictor based on common variants may be important for follow-up studies that aim to identify alternative causal factors. Using genome-wide imputed genetic data, we aimed to classify 158,951 unrelated individuals from the UK Biobank...

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Identifiers

PMID: 37733769
DOI: 10.1371/journal.pgen.1010934
PMCID: PMC10564121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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