Genetic risk for high body mass index before and amidst the obesity epidemic: Cross-cohort analysis of four british birth cohort studies.

Abstract excerpt

Obesity is a highly heritable trait, but rising obesity rates suggest environmental change is also of profound importance. We conducted a cross-cohort analysis to examine how associations between genetic risk for high BMI and observed BMI differed in four British birth cohorts born before and amidst the obesity epidemic (1946, 1958, 1970 and ~2001; N = 19,379). BMI (kg/m2) was measured at multiple time points...

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