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Article

Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records.

Nature communications - 10 Jul 2024

Venkatesh Samvida S, Ganjgahi Habib, Palmer Duncan S, Coley Kayesha, Linchangco Gregorio V, Hui Qin, Wilson Peter, Ho Yuk-Lam, Cho Kelly, Arumäe Kadri, Wittemans Laura B L, Nellåker Christoffer, Vainik Uku, Sun Yan V, Holmes Chris, Lindgren Cecilia M, Nicholson George

Abstract excerpt

Obesity is a heritable disease, characterised by excess adiposity that is measured by body mass index (BMI). While over 1,000 genetic loci are associated with BMI, less is known about the genetic contribution to adiposity trajectories over adulthood. We derive adiposity-change phenotypes from 24.5 million primary-care health records in over 740,000 individuals in the UK Biobank, Million Veteran Program USA, and...

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Identifiers

PMID: 38987242
DOI: 10.1038/s41467-024-49998-0
PMCID: PMC11237142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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