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Article

Genetically predicted cerebrospinal fluid metabolite levels and risk of sudden sensorineural hearing loss: A Mendelian randomization study.

Medicine - 30 Jan 2026

Xuyu Zu, Guolin Tan, Jianbo Feng, Xiaoli Zhang

Abstract excerpt

Sudden sensorineural hearing loss (SSNHL) is an idiopathic condition lacking reliable biomarkers or established causal mechanisms. While systemic metabolic dysregulation has been implicated, the specific role of central nervous system metabolites remains unexplored. We applied a 2-sample Mendelian randomization framework to evaluate the causal influence of cerebrospinal fluid (CSF) metabolites on SSNHL risk....

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Identifiers

PMID: 41630328
DOI: 10.1097/MD.0000000000047422
PMCID: PMC12863793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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