Genetic evidence for the effect of prepregnancy maternal metabolic status on the risk of congenital heart disease in offspring: A Mendelian randomization study.

Abstract excerpt

Congenital heart disease (CHD) is the most common birth defect in the world and is still one of the most common causes of illness and death in babies. There are links between maternal metabolic factors, like glycemic and lipid profiles, and the disease, but it is not clear if these links are causal. Using a two-sample Mendelian randomization (MR) method, this study looked at whether maternal HbA1c, fasting...

Topics

• Humans
• Mendelian Randomization Analysis
• Female
• Heart Defects, Congenital
• Pregnancy
• Polymorphism, Single Nucleotide