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The effect of maternal BMI, smoking and alcohol on congenital heart diseases: a Mendelian randomisation study

31 Jan 2023

Abstract excerpt

BACKGROUND: Congenital heart diseases (CHDs) remain a significant cause of infant morbidity and mortality. Epidemiological studies have explored maternal risk factors for offspring CHDs, but few have used genetic epidemiology methods to improve causal inference. METHODS: Three birth cohorts, including 65,510 mother/offspring pairs (N = 562 CHD cases) were included. We used Mendelian randomisation (MR) analyses to...

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PMID: 36721200
DOI: 10.1186/s12916-023-02731-y

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