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Article

Causal Associations between Pre-pregnancy Obesity Traits and Hypertensive Disorders of Pregnancy: A Two-Sample Mendelian Randomization Analyses.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC - 1 Mar 2026

Hu Mengjin, Xia Jinggang, Yin Chunlin

Abstract excerpt

OBJECTIVE: To investigate potential causal effects of pre-pregnancy obesity traits on hypertensive disorders of pregnancy-gestational hypertension, preeclampsia, and eclampsia-using genetic epidemiology approaches. METHODS: We performed a comprehensive 2-sample Mendelian randomization (MR) analysis leveraging summary statistics from large-scale genome-wide association studies. Eleven adiposity-related exposure...

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PMID: 41005619
DOI: 10.1016/j.jogc.2025.103070

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