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Article

Blood Cultures Contain Populations of Genetically Diverse Candida albicans Strains that May Differ in Echinocandin Tolerance and Fitness.

The Journal of infectious diseases - 17 Mar 2026

Fleres Giuseppe, Cheng Shaoji, Badrane Hassan, Dupont Christopher L, Espinoza Josh L, Abbey Darren, Driscoll Eileen, Newbrough Anthony, Hao Binghua, Mansour Akila, Nguyen M Hong, Clancy Cornelius J

Abstract excerpt

BACKGROUND: It is unknown whether within-patient Candida albicans diversity is common during bloodstream infections (BSIs). METHODS: We determined whole genome sequences of 10 C. albicans strains from blood cultures (BCs) in each of 4 patients. We performed detailed phenotypic studies on strains from 1 patient. RESULTS: BCs in 3 patients contained mixed populations of strains that differed by large-scale genetic...

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Identifiers

PMID: 41026105
DOI: 10.1093/infdis/jiaf495
PMCID: PMC13017712

Genes

NRG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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