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Article

Genotypic diversity and unrecognized antifungal resistance among populations of Candida glabrata from positive blood cultures.

Nature communications - 22 Sept 2023

Badrane Hassan, Cheng Shaoji, Dupont Christopher L, Hao Binghua, Driscoll Eileen, Morder Kristin, Liu Guojun, Newbrough Anthony, Fleres Giuseppe, Kaul Drishti, Espinoza Josh L, Clancy Cornelius J, Nguyen M Hong

Abstract excerpt

The longstanding model is that most bloodstream infections (BSIs) are caused by a single organism. We perform whole genome sequencing of five-to-ten strains from blood culture (BC) bottles in each of ten patients with Candida glabrata BSI. We demonstrate that BCs contain mixed populations of clonal but genetically diverse strains. Genetically distinct strains from two patients exhibit phenotypes that are...

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Identifiers

PMID: 37739935
DOI: 10.1038/s41467-023-41509-x
PMCID: PMC10516878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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