Article
Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate and Glycine in Adult Subjects With Brainstem Gliomas.
NMR in biomedicine - 1 Jan 2025
Tiwari Vivek, Ganji Sandeep K, An Zhongxu, Pinho Marco C, Davis Larry T, McKnight Colin D, Berry Julia D, Mobley Bret C, Luo Leo Y, Mohler Alexander C, Merrell Ryan T, Kelly Patrick D, Thompson Reid C, Mickey Bruce E, Malloy Craig R, Gore John C, Patel Toral R, Maher Elizabeth A, Choi Changho
Abstract excerpt
Surgical biopsy of brainstem tumors carries a risk of neurological injury. We performed magnetic resonance spectroscopy (MRS) of 2-hydroxyglutarate (2HG) and glycine in patients with brainstem tumors to assess the feasibility of detecting and quantifying 2HG in the brainstem to obviate the need for a diagnostic biopsy and to establish the clinical significance of glycine MRS in brainstem tumors in vivo. Twenty...
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