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Article

2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.

Nature medicine - 26 Jan 2012

Choi Changho, Ganji Sandeep K, DeBerardinis Ralph J, Hatanpaa Kimmo J, Rakheja Dinesh, Kovacs Zoltan, Yang Xiao-Li, Mashimo Tomoyuki, Raisanen Jack M, Marin-Valencia Isaac, Pascual Juan M, Madden Christopher J, Mickey Bruce E, Malloy Craig R, Bachoo Robert M, Maher Elizabeth A

Abstract excerpt

Mutations in isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) have been shown to be present in most World Health Organization grade 2 and grade 3 gliomas in adults. These mutations are associated with the accumulation of 2-hydroxyglutarate (2HG) in the tumor. Here we report the noninvasive detection of 2HG by proton magnetic resonance spectroscopy (MRS). We developed and optimized the pulse sequence with...

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Identifiers

PMID: 22281806
DOI: 10.1038/nm.2682
PMCID: PMC3615719

Genes

IDH1
IDH2

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Related research

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2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.PMID 22281806Read ↗

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Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy.Semantic proximity Read ↗

In-Vivo Proton Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate in Isocitrate Dehydrogenase-Mutated Gliomas: A Technical Review for Neuroradiologists.Semantic proximity Read ↗

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